Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OY-101, an orally active compound, serves as a potent and specific inhibitor of P-glycoprotein (P-gp). It has the capability to sensitize drug-resistant tumors and counteract tumor multidrug resistance efficiently. Compared to Tetrandrine [1], OY-101 demonstrates enhanced water-solubility, cytotoxicity, and reversal activity.
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Description | OY-101, an orally active compound, serves as a potent and specific inhibitor of P-glycoprotein (P-gp). It has the capability to sensitize drug-resistant tumors and counteract tumor multidrug resistance efficiently. Compared to Tetrandrine [1], OY-101 demonstrates enhanced water-solubility, cytotoxicity, and reversal activity. |
In vitro | OY-101 exhibits a remarkable synergistic anticancer effect with Vincristine in multidrug-resistant Eca109/VCR cells, with an IC50 of 9.9 ± 1.3 nM[1]. OY-101 (0-5 μM) demonstrates negligible toxicity to Eca109/VCR cells and significantly enhances Vincristine sensitivity within these cells[1]. |
In vivo | OY-101, administered at a dose of 30 mg/kg every other day via oral gavage for a duration of three weeks, was observed to enhance the sensitization to vincristine in vivo without apparent toxicity [1]. Additionally, OY-101 demonstrated favorable pharmacokinetics with both intravenous administration (3 mg/kg) and oral administration (30 mg/kg) in single doses [1]. |
Molecular Weight | 433.548 |
Formula | C27H31NO4 |
CAS No. | 41183-02-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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OY-101 41183-02-2 inhibitor inhibit