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PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | TBD | 35 days | |
1 mg | TBD | 35 days |
Description | PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMF: 30 mg/mL, Sonication is recommended. Ethanol:PBS (pH 7.2) (1:6): 0.14 mg/mL, Sonication is recommended. Ethanol: 30 mg/mL, Sonication is recommended. DMSO: 30 mg/mL, Sonication is recommended. |
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