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Quercetin 3-gentiobioside

Name: Quercetin 3-gentiobioside
Brand: TargetMol
SKU: TN2122
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2122Cas No. 7431-83-6

Alias Quercetin-3-gentiobioside

Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and the formation of advanced glycosylation end products (AGEs).

Quercetin 3-gentiobioside

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Purity: 99.94%

Catalog No. TN2122Alias Quercetin-3-gentiobiosideCas No. 7431-83-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$109	-	In Stock
5 mg	$276	-	In Stock
10 mg	$469	-	In Stock
25 mg	$759	-	In Stock
50 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$393	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and the formation of advanced glycosylation end products (AGEs).
Targets&IC50	AGE:109.46±1.41, AR:10.6±0.38
In vitro	We led to isolation of Quercetin-3-gentiobioside was first reported on the isolation from A. iwayomogi. A. iwayomogi extracts showed significant inhibitor on AR and AGEs formation activities[1] We also determined quercetin 3-O-gentiobioside have antioxidant activity in vitro.[2]
In vivo	Treatment with quercetin 3-O-gentiobioside (HF diet-induced obese mice; 0.1% Iso and Que) reduced blood glucose and serum insulin levels and improved glucose tolerance in obese mice. Meanwhile, serum triglyceride levels and liver morphology in the mice were significantly ameliorated by EO and isoquercitrin treatment. Total cholesterol levels in quercetin 3-O-gentiobioside treated mice were also reduced.[2]
Synonyms	Quercetin-3-gentiobioside

Chemical Properties

Molecular Weight	626.52
Formula	C₂₇H₃₀O₁₇
Cas No.	7431-83-6
Smiles	OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.89 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (143.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5961 mL	7.9806 mL	15.9612 mL	79.8059 mL
5 mM	0.3192 mL	1.5961 mL	3.1922 mL	15.9612 mL
10 mM	0.1596 mL	0.7981 mL	1.5961 mL	7.9806 mL
20 mM	0.0798 mL	0.3990 mL	0.7981 mL	3.9903 mL
50 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5961 mL
100 mM	0.0160 mL	0.0798 mL	0.1596 mL	0.7981 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc