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MC-Gly-Gly-Phe-Gly-GABA-Exatecan

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Catalog No. T87847Cas No. 1599439-52-7

MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM.

MC-Gly-Gly-Phe-Gly-GABA-Exatecan

MC-Gly-Gly-Phe-Gly-GABA-Exatecan

😃Good
Catalog No. T87847Cas No. 1599439-52-7
MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM.
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Product Introduction

Bioactivity
Description
MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM.
In vitro
MC-Gly-Gly-Phe-Gly-GABA-Exatecan (0-10 μM) exhibits cytotoxicity by targeting antibodies CD30, CD33, CD70, and B7-H3 in the cell lines SR (CD30 positive), HL60 (CD33 positive), U251 (CD70 positive), and Calu-6 (B7-H3 positive) [2]. Cell Viability Assay [2] was conducted using SR, HL60, U251, and Calu-6 with a concentration range of 0-10 μM over 6 days, resulting in reduced cell viability.
In vivo
The compound MC-Gly-Gly-Phe-Gly-GABA-Exatecan, administered intravenously at 10 mg/kg once weekly for two weeks, demonstrates antitumor activity in A375 xenograft mice, resulting in inhibited tumor growth and induced tumor regression [2].
Chemical Properties
Molecular Weight1032.08
FormulaC53H58FN9O12
Cas No.1599439-52-7
SmilesN(C(CCCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

DrugLinkerConjugatesforADCDrugLinker Conjugates for ADC
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