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Prafnosbart
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Catalog No. T81410Cas No. 2566473-71-8
Alias DS-6016A
Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody that specifically targets Activin A Receptor Type 1 (ACVR1/ALK2). By binding to ACVR1, Prafnosbart blocks the binding of Activin A and the subsequent abnormal activation of downstream SMAD1/5/8 signaling pathways, thereby inhibiting the formation of heterotopic ossification (HO). Prafnosbart is primarily used to investigate bone metabolic disorders associated with ACVR1 mutations, such as Fibrodysplasia Ossificans Progressiva (FOP).
Prafnosbart
Prafnosbart
Copy Product Info😃Good
Catalog No. T81410Alias DS-6016ACas No. 2566473-71-8
Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody that specifically targets Activin A Receptor Type 1 (ACVR1/ALK2). By binding to ACVR1, Prafnosbart blocks the binding of Activin A and the subsequent abnormal activation of downstream SMAD1/5/8 signaling pathways, thereby inhibiting the formation of heterotopic ossification (HO). Prafnosbart is primarily used to investigate bone metabolic disorders associated with ACVR1 mutations, such as Fibrodysplasia Ossificans Progressiva (FOP).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody that specifically targets Activin A Receptor Type 1 (ACVR1/ALK2). By binding to ACVR1, Prafnosbart blocks the binding of Activin A and the subsequent abnormal activation of downstream SMAD1/5/8 signaling pathways, thereby inhibiting the formation of heterotopic ossification (HO). Prafnosbart is primarily used to investigate bone metabolic disorders associated with ACVR1 mutations, such as Fibrodysplasia Ossificans Progressiva (FOP). |
| Synonyms | DS-6016A |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | ACVR1 |
| Cas No. | 2566473-71-8 |
| Isotype | IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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