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L-Threonine

Name: L-Threonine
Brand: TargetMol
SKU: T2O2777
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2O2777Cas No. 72-19-5

Alias threonine

L-Threonine (threonine) is an essential amino acid in humans,an important amino acid for the nervous system,L-Threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression.

L-Threonine

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Purity: 98.87%

Catalog No. T2O2777Alias threonineCas No. 72-19-5

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$38	In Stock	In Stock
5 g	$62	-	In Stock
10 g	$76	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

L-Threonine AI Summary

L-Threonine, with a partition coefficient (logP) value of 2.91, demonstrates moderate to high hydrophobicity. It has shown significant bioactivity by inhibiting Phenylalanine dehydrogenase of Sporosarcina species by 61.0%, and it has antiviral properties, notably blocking the entry of the Ebola virus with AC50 values ranging from 316.2 nM to 6.31 uM. Additionally, it inhibits the cytotoxic effects of SARS-CoV-2 on VERO-6 and Caco-2 cells at 10 uM concentration, although the potency varies, with inhibition rates of -1.21% and 0.21% respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease activity by 8.188% at a concentration of 20 µM. In rat hippocampal astrocytes, L-Threonine inhibits ASCT2 mediated [3H]-D-serine uptake by 25.0% at 1 mM concentration. Despite these activities, it did not exhibit significant bioactivity against numerous human and rat receptor and enzyme targets in various assays, with AC50 values exceeding 30000.0 nM. Furthermore, L-Threonine has an Rf value of 0.54 under specified chromatographic conditions, which provides useful insights into its chromatographic behavior. In human HDAC6 enzymatic assays, higher inhibition was observed using a commercial peptide substrate compared to a custom one, and a 20.0% inhibition was recorded against PKM2 of unknown origin..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Threonine (threonine) is an essential amino acid in humans,an important amino acid for the nervous system,L-Threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression.
Synonyms	threonine

Chemical Properties

Molecular Weight	119.12
Formula	C₄H₉NO₃
Cas No.	72-19-5
Smiles	[C@H]([C@@H](C)O)(C(O)=O)N
Relative Density.	1.077 g/cm3. Temperature:22.5 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 33.3 mg/mL (279.55 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	8.3949 mL	41.9745 mL	83.9490 mL	419.7448 mL
5 mM	1.6790 mL	8.3949 mL	16.7898 mL	83.9490 mL
10 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
20 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
50 mM	0.1679 mL	0.8395 mL	1.6790 mL	8.3949 mL
100 mM	0.0839 mL	0.4197 mL	0.8395 mL	4.1974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc