Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam can be used in Alzheimer's disease research[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 6-8 weeks | $ 1,149.00 | |
200 mg | 6-8 weeks | $ 1,723.00 |
Description | Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam can be used in Alzheimer's disease research[1]. |
In vitro | Simufilam (1 pM~1 nM) dose-dependently improves Arc expression induced by NMDA/glycine[1]. Simufilam (1 nM, 1 hour) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs [1]. |
In vivo | Simufilam (P.o.; 2 months) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) strongly reduces FLNAea7nAChR/TLR4 associations. Simufilam significantly improves spatial memory. Simufilam significantly improves working memory [1]. |
Molecular Weight | 259.35 |
Formula | C15H21N3O |
CAS No. | 1224591-33-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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