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Grisnilimab setaritox

Catalog No. T82259 CAS 2361013-29-6

Synonyms: WT1-RTA

Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA component disrupts the function of 60S ribosomal subunits. Additionally, Grisnilimab setaritox has demonstrated efficacy in ameliorating leukemic meningitis in a rhesus monkey model [1].

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Grisnilimab setaritox, CAS 2361013-29-6

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Description	Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA component disrupts the function of 60S ribosomal subunits. Additionally, Grisnilimab setaritox has demonstrated efficacy in ameliorating leukemic meningitis in a rhesus monkey model [1].
In vitro	Grisnilimab setaritox (2.5 μg/mL; 24 h) exhibits cytotoxicity against T-lymphoblastic leukemia CEM cells [1].
In vivo	Grisnilimab setaritox (60 μg, 120 μg; intrathecal or intravenous injection; single dose) demonstrated potential in inhibiting T-ALL meningeal leukemia in a rhesus macaque model [1]. Grisnilimab setaritox (60 μg; intravenous injection; once weekly for six weeks, or daily for seven days) caused CSF granulocytosis and anti-immunotoxin antibodies in a rhesus macaque model [1].

Synonyms	WT1-RTA
Molecular Weight	N/A
CAS No.	2361013-29-6

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Grisnilimab setaritox 2361013-29-6 WT1-RTA inhibitor inhibit

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