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PROTAC CDK9 degrader-6

Catalog No. T74852 CAS 2935587-91-8

PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and CDK9 55 isoforms, respectively [1].

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PROTAC CDK9 degrader-6 Chemical Structure

PROTAC CDK9 degrader-6, CAS 2935587-91-8

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Description	PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and CDK9 55 isoforms, respectively [1].
Targets&IC50	CDK9 55:0.05 μM (DC50), CDK9 42:0.03 μM (DC50)
In vitro	PROTAC CDK9 degrader-6 (compound 16) (1 μM; 6 hours) reduces the protein levels of MCL2 and induces competitive degradation of CDK9 in MV411 cells [1]. Furthermore, PROTAC CDK9 degrader-6 (1 μM; 1-6 hours) diminishes the protein levels of MCL2 and CDK9 in a time-dependent manner, maintaining inhibition for 24 hours [1].

Molecular Weight	878.8
Formula	C42H49Cl2N9O8
CAS No.	2935587-91-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

PROTAC CDK9 degrader-6 2935587-91-8 Cell Cycle/Checkpoint CDK inhibitor inhibit

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