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TPPS

Name: TPPS
Brand: TargetMol
SKU: T78448
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T78448Cas No. 35218-75-8

Tetraphenylporphine sulfonate (TPPS) serves as a non-cytotoxic probe suitable for tumor localization detection [1].

TPPS

🥰Excellent

Catalog No. T78448Cas No. 35218-75-8

Tetraphenylporphine sulfonate (TPPS) serves as a non-cytotoxic probe suitable for tumor localization detection [1].

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Product Introduction

Bioactivity

Description	Tetraphenylporphine sulfonate (TPPS) serves as a non-cytotoxic probe suitable for tumor localization detection [1].
In vitro	TPPS (0-20 µg/mL) demonstrates no cytotoxicity in Vero and HEp-2 cell lines in vitro, with its primary localization observed within the soluble and protein fractions of the cells [1].
In vivo	TPPS4 exhibits the highest tumor-to-tissue ratios 96 hours post-injection, demonstrating dose-dependent behavior [2]. The compound is primarily eliminated via renal clearance, with its absolute concentrations in the kidneys diminishing over time following administration [2].

Chemical Properties

Molecular Weight	934.99
Formula	C₄₄H₃₀N₄O₁₂S₄
Cas No.	35218-75-8
Smiles	O=S(=O)(O)C=1C=CC(=CC1)C=2C3=NC(C=C3)=C(C4=CC=C(C=C4)S(=O)(=O)O)C5=CC=C(N5)C(=C6N=C(C=C6)C(C7=CC=C(C=C7)S(=O)(=O)O)=C8C=CC2N8)C=9C=CC(=CC9)S(=O)(=O)O

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc