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Gummiferin dipotassium

Name: Gummiferin dipotassium
Brand: TargetMol
SKU: T8204
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8204Cas No. 33286-30-5

Alias Dipotassium carboxyatractyloside

Gummiferin dipotassium exhibits antifungal activity against Saccharomyces cerevisiae and can be used in biochemical experiments and drug synthesis research.

Gummiferin dipotassium

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Purity: 98%

Catalog No. T8204Alias Dipotassium carboxyatractylosideCas No. 33286-30-5

Gummiferin dipotassium exhibits antifungal activity against Saccharomyces cerevisiae and can be used in biochemical experiments and drug synthesis research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$78	-	In Stock
10 mg	$118	-	In Stock
25 mg	$198	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$108	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

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COA HNMR MS

Product Introduction

Bioactivity

Description	Gummiferin dipotassium exhibits antifungal activity against Saccharomyces cerevisiae and can be used in biochemical experiments and drug synthesis research.
In vitro	Gummiferin dipotassium (10-25 μM, 48 hours) can induce death in mouse primary pulmonary endothelial cells and exacerbate mitochondrial dysfunction, specifically manifested as mitochondrial membrane potential depolarization, increased reactive oxygen species generation, and opening of the mitochondrial permeability transition pore [2]. Gummiferin dipotassium (2 μM) can induce Ca²⁺ release in aged rat liver mitochondria, while triggering mitochondrial swelling and membrane potential collapse [3].
In vivo	Gummiferin dipotassium (13.5 mg/kg, intraperitoneal injection) can induce behavioral manifestations such as drowsiness, fatigue, and epileptic seizure in rats, and cause histopathological damage to the liver and kidneys, specifically manifested as hepatic cell vacuolar degeneration, necrosis, and renal tubular necrosis [5].
Synonyms	Dipotassium carboxyatractyloside

Chemical Properties

Molecular Weight	847.00
Formula	C₃₁H₄₄K₂O₁₈S₂
Cas No.	33286-30-5
Smiles	C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)([O-])=O)OS(=O)([O-])=O)OC(CC(C)C)=O)C(O)=O)C[C@@](C([C@@H]4O)=C)([H])CC3.[K+].[K+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.00 mg/mL (23.61 mM), Sonication is recommended.

H2O: 80.00 mg/mL (94.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.1806 mL	5.9032 mL	11.8064 mL	59.0319 mL
5 mM	0.2361 mL	1.1806 mL	2.3613 mL	11.8064 mL
10 mM	0.1181 mL	0.5903 mL	1.1806 mL	5.9032 mL
20 mM	0.0590 mL	0.2952 mL	0.5903 mL	2.9516 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0236 mL	0.1181 mL	0.2361 mL	1.1806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc