Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO-B-IN-4 (Compound 26) is a reversible monoamine oxidase B (MAO-B) inhibitor with potent in vitro activity, characterized by an IC50 value of 9 nM. This orally active compound exhibits favorable metabolic stability, a satisfactory safety profile, and effective brain permeability. Demonstrating antidepressant effects in rodent models, MAO-B-IN-4 is suitable for research into Alzheimer's disease [1].
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Description | MAO-B-IN-4 (Compound 26) is a reversible monoamine oxidase B (MAO-B) inhibitor with potent in vitro activity, characterized by an IC50 value of 9 nM. This orally active compound exhibits favorable metabolic stability, a satisfactory safety profile, and effective brain permeability. Demonstrating antidepressant effects in rodent models, MAO-B-IN-4 is suitable for research into Alzheimer's disease [1]. |
In vitro | MAO-B-IN-4, at a concentration of 0.25 μM when exposed to 0.5μM DOX for 24 hours, exhibited significant neuroglial protective effects in cultured astrocytic cell models [1]. |
In vivo | MAO-B-IN-4 (1 and 3 mg/kg, orally, 2 h) can prevent scopolamine-induced short-term memory impairment [1]. MAO-B-IN-4 (0.312-2.5 mg/kg, intravenous injection, 1 h) exhibits antidepressant-like properties in mice during the forced swim test [1]. |
Molecular Weight | 411.87 |
Formula | C23H20ClF2N3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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MAO-B-IN-4 Neuroscience Monoamine Oxidase inhibitor inhibit