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Sulindac sulfide

Name: Sulindac sulfide
Brand: TargetMol
SKU: T13037
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13037Cas No. 49627-27-2

Alias cis-Sulindac sulfide

Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid.

Sulindac sulfide

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Purity: 99.35%

Catalog No. T13037Alias cis-Sulindac sulfideCas No. 49627-27-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$44	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.35%

Appearance:Solid

Color:Orange

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COA FNMR LCMS HNMR

Product Introduction

Bioactivity

Description	Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid.
Targets&IC50	γ42-secretase:20.2 μM , γ42-secretase:20.2 μM, COX-1:1.9 µM, COX-2:1.21 µM, Aldose reductase:279 nM
In vitro	Treatment with 100 μM of Sulindac sulfide (SSide) induces apoptosis leading to significant reduction in Aβ generation and total protein expression. The IC50 for Aβ42 secretion of SSide is 30.6±2.8 μM. SSide inhibits γ42-secretase activity dose-dependently, with an IC50 of 20.2±2.6 μM. Increasing SSide concentration decreases the slope in the rate vs. enzyme concentration plot, indicating SSide is not an irreversible or pseudo-irreversible inhibitor. After pretreatment of the dialyzed solubilized γ-secretase fraction with SSide and subsequent exposure to CHAPSO buffer without SSide, γ-secretase activity almost fully recovers. This strongly suggests that SSide targets the γ-secretase complex as a reversible inhibitor. [1]
In vivo	Sulindac sulfide also inhibits aldose reductase, blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications.[2] Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.[5]
Synonyms	cis-Sulindac sulfide

Chemical Properties

Molecular Weight	340.41
Formula	C₂₀H₁₇FO₂S
Cas No.	49627-27-2
Smiles	C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(SC)C=C3
Relative Density.	1.3g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (734.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9376 mL	14.6882 mL	29.3763 mL	146.8817 mL
5 mM	0.5875 mL	2.9376 mL	5.8753 mL	29.3763 mL
10 mM	0.2938 mL	1.4688 mL	2.9376 mL	14.6882 mL
20 mM	0.1469 mL	0.7344 mL	1.4688 mL	7.3441 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	2.9376 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc