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Anti-MHC Class II Polyclonal Antibody
😃Good
Catalog No. TMAB-01134
Alias RING7, RING6, MHC2, MHC DPB1, MHC class II antigen DMB, Major histocompatibility complex class II DP beta 1, Major histocompatibility complex class II, HLADP1B, HLA-DMβ, HLA-DMB, HLADM, HLA DPB1, HLA DMB, HLA class II histocompatibility antigen, DM beta chain, HLA class II histocompatibility antigen DM beta chain, DRB, DPB1, DPB 1, DP beta 1, DMB, DMA
Anti-MHC Class II Polyclonal Antibody is a Rabbit antibody targeting MHC Class II. Anti-MHC Class II Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-MHC Class II Polyclonal Antibody
Anti-MHC Class II Polyclonal Antibody
😃Good
Catalog No. TMAB-01134Alias RING7, RING6, MHC2, MHC DPB1, MHC class II antigen DMB, Major histocompatibility complex class II DP beta 1, Major histocompatibility complex class II, HLADP1B, HLA-DMβ, HLA-DMB, HLADM, HLA DPB1, HLA DMB, HLA class II histocompatibility antigen, DM beta chain, HLA class II histocompatibility antigen DM beta chain, DRB, DPB1, DPB 1, DP beta 1, DMB, DMA
Anti-MHC Class II Polyclonal Antibody is a Rabbit antibody targeting MHC Class II. Anti-MHC Class II Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MHC Class II Polyclonal Antibody is a Rabbit antibody targeting MHC Class II. Anti-MHC Class II Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | RING7, RING6, MHC2, MHC DPB1, MHC class II antigen DMB, Major histocompatibility complex class II DP beta 1, Major histocompatibility complex class II, HLADP1B, HLA-DMβ, HLA-DMB, HLADM, HLA DPB1, HLA DMB, HLA class II histocompatibility antigen, DM beta chain, HLA class II histocompatibility antigen DM beta chain, DRB, DPB1, DPB 1, DP beta 1, DMB, DMA |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | Tissue/cell: Human pancreatic cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-HLA DMβ Polyclonal Antibody, Unconjugated (TMAB-01134) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human MHC Class II |
| Antigen Species | Human |
| Gene Name | HLA-DMB |
| Gene ID | |
| Protein Name | HLA class II histocompatibility antigen, DM beta chain |
| Uniprot ID | |
| Biology Area | Class II |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
| Molecular Weight | Theoretical: 29 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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