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β-Aminoarteether maleate
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Catalog No. T87693Cas No. 133162-25-1
Alias SM934
β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1].
β-Aminoarteether maleate
😃Good
Catalog No. T87693Alias SM934Cas No. 133162-25-1
β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1]. |
| In vitro | β-Aminoarteether (SM934; 10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.[1] In vitro, β-Aminoarteether (SM934) suppresses Th1 and Th17 polarization without influencing Treg differentiation.[1] |
| In vivo | The treatment with β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daily; for 3 months) significantly delays the progression of glomerulonephritis and increases survival rates in female NZB/W F1 mice (six and half months old). Additionally, β-Aminoarteether treatment promotes IL-10 production by macrophages from these mice [1]. |
| Synonyms | SM934 |
| Molecular Weight | 443.49 |
| Formula | C21H33NO9 |
| Cas No. | 133162-25-1 |
| Smiles | C(=C\C(O)=O)\C(O)=O.C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN)[H])[H] |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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