β-Aminoarteether maleate

Name: β-Aminoarteether maleate
Brand: TargetMol
SKU: T87693
Rating: 4.5 (1 reviews)

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Catalog No. T87693Cas No. 133162-25-1

Alias SM934

β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1].

β-Aminoarteether maleate

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Catalog No. T87693Alias SM934Cas No. 133162-25-1

β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1].

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	β-Aminoarteether maleate (SM934), an orally active derivative of Artemisinin, is utilized in the research of inflammation and autoimmune diseases, including lupus [1].
In vitro	β-Aminoarteether (SM934; 10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.[1] In vitro, β-Aminoarteether (SM934) suppresses Th1 and Th17 polarization without influencing Treg differentiation.[1]
In vivo	The treatment with β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daily; for 3 months) significantly delays the progression of glomerulonephritis and increases survival rates in female NZB/W F1 mice (six and half months old). Additionally, β-Aminoarteether treatment promotes IL-10 production by macrophages from these mice [1].
Synonyms	SM934

Chemical Properties

Molecular Weight	443.49
Formula	C₂₁H₃₃NO₉
Cas No.	133162-25-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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