Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
7400 μg | 35 days | $ 473.00 |
Description | 8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells. |
Synonyms | 8-bromo Nicotinamide adenine dinucleotide, N(8-bromo-A)D+ |
Molecular Weight | 764.30 |
Formula | C21H25BrN7O14P2.Na |
CAS No. | 2022926-16-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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8-bromo NAD+ sodium 2022926-16-3 8-bromo Nicotinamide adenine dinucleotide N(8-bromo-A)D+ inhibitor inhibit