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CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc)
(Synonyms: TNLG8A, TNFSF7, LPFS3, CD27LG, CD27-L, CD27L) Copy Product InfoSynonyms: TNLG8A, TNFSF7, LPFS3, CD27LG, CD27-L, CD27L
Catalog No. TMPY-07034 Copy Product Info
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $55 | 7-10 days | 7-10 days | |
| 10 µg | $87 | 7-10 days | 7-10 days | |
| 20 µg | $142 | 7-10 days | 7-10 days | |
| 50 µg | $277 | 7-10 days | 7-10 days | |
| 100 µg | $535 | 7-10 days | 7-10 days | |
| 200 µg | $793 | 7-10 days | 7-10 days | |
| 500 µg | $1,690 | 7-10 days | 7-10 days | |
| 1 mg | $3,420 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized CD27 Protein, Human, Recombinant (His) (Cat#TMPY-03401) at 2 μg/mL (100 μL/well) can bind CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) (Cat#TMPY-07034), the EC50 is 2-6 ng/mL. |
| Description | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | P32970-1 |
| Construction | A DNA sequence encoding the Human CD70(NP_001243.1) (Gln39-Pro193) was expressed with the Fc region of human IgG1 at the N-terminus. This construct has a trimer design. |
| Protein Purity | ≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Please refer to the lot-specific COA. |
| Synonyms | TNLG8A, TNFSF7, LPFS3, CD27LG, CD27-L, CD27L |
| Research Background | CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Molecular Weight | 79.83 kDa (predicted); 140.1 kDa (non-reducing contition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) chemical structure | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) molecular weight
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