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(S,R,S)-AHPC-PEG2-C4-Cl

Name: (S,R,S)-AHPC-PEG2-C4-Cl
Brand: TargetMol
SKU: T17910
Rating: 4.5 (1 reviews)

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Catalog No. T17910Cas No. 1835705-57-1

Alias VHL Ligand-Linker Conjugates 7, VH032-PEG2-C4-Cl, E3 ligase Ligand-Linker Conjugates 10

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-PEG2-C4-Cl

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Catalog No. T17910Alias VHL Ligand-Linker Conjugates 7, VH032-PEG2-C4-Cl, E3 ligase Ligand-Linker Conjugates 10Cas No. 1835705-57-1

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$61	5 days	5 days
5 mg	$98	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro	(S,R,S)-AHPC-PEG2-C4-Cl employs the VHL ligand to facilitate the development of PROTACs targeting the oncogenic tyrosine kinase BCR-ABL, using a 6-2-2 linker that balances hydrophobicity and hydrophilicity. This compound can conjugate with potent tyrosine kinase inhibitors (TKIs) like bosutinib and dasatinib to promote the degradation of c-ABL and BCR-ABL via CRBN or VHL E3 ubiquitin ligase mechanisms.
Synonyms	VHL Ligand-Linker Conjugates 7, VH032-PEG2-C4-Cl, E3 ligase Ligand-Linker Conjugates 10

Chemical Properties

Molecular Weight	651.26
Formula	C₃₂H₄₇ClN₄O₆S
Cas No.	1835705-57-1
Smiles	C([C@@H](NC(COCCOCCCCCCCl)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Relative Density.	1.218 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (76.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5355 mL	7.6774 mL	15.3549 mL	76.7743 mL
5 mM	0.3071 mL	1.5355 mL	3.0710 mL	15.3549 mL
10 mM	0.1535 mL	0.7677 mL	1.5355 mL	7.6774 mL
20 mM	0.0768 mL	0.3839 mL	0.7677 mL	3.8387 mL
50 mM	0.0307 mL	0.1535 mL	0.3071 mL	1.5355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc