This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Peldesine dihydrochloride
Catalog No. T60799 CAS
2772702-10-8
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), exhibiting IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mouse red blood cell (RBC) PNP, respectively. Additionally, it acts as an inhibitor of T-cell proliferation with an IC50 of 800 nM. This compound shows promise for research into cutaneous T-cell lymphoma, psoriasis, and HIV infection [1] [2] [3] [4].
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Contact us for more batch information
Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), exhibiting IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mouse red blood cell (RBC) PNP, respectively. Additionally, it acts as an inhibitor of T-cell proliferation with an IC50 of 800 nM. This compound shows promise for research into cutaneous T-cell lymphoma, psoriasis, and HIV infection [1] [2] [3] [4].
In vitro
Peldesine (BCX 34; 0-50 μM; 72 hours; Jurkat cells) effectively inhibits T-cell proliferation at concentrations below 10 μM when combined with 10 μM dGuo, without impacting B-cell proliferation. This action suggests Peldesine predominantly affects a later phase of T-cell activation via an IL-2-independent mechanism, indicating its potential to selectively suppress T-cell immune responses. Furthermore, Peldesine demonstrates significant inhibitory effects on human leukemia CCRF-CEM T-cell proliferation (IC 50 of 0.57 μM) in the presence of deoxyguanosine, while not affecting rat or mouse T-cell proliferation at concentrations up to 30 μM. These findings highlight Peldesine's specific inhibitory action on certain T-cell lines under defined conditions.
Molecular Weight
314.17
Formula
C12H13Cl2N5O
CAS No.
2772702-10-8
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
More
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.