Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = <10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 110.00 | |
10 mg | 35 days | $ 210.00 | |
25 mg | 35 days | $ 483.00 | |
50 mg | 35 days | $ 889.00 |
Description | ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose. |
Molecular Weight | 449.44 |
Formula | C22H18F3NO4S |
CAS No. | 2314465-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL
DMSO: 30 mg/mL
DMF: 30 mg/mL
You can also refer to dose conversion for different animals. More
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ZLY032 2314465-67-1 ZLY 032 ZLY-032 inhibitor inhibit