Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1].
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Description | NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1]. |
In vivo | NDBM exhibits lower fluorescence intensity in normal cells (HUVEC, RAW 264.7 cell lines) compared to tumor cells (MGC-803, HepG2, and Hela cell lines) [1]. At concentrations of 2.5, 5, 10, and 20 μM over 18 hours, NDBM reduces the viability of tumor cells (MGC-803, HepG2, and Hela) [1]. |
Molecular Weight | 679.56 |
Formula | C33H35BrN4O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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NDBM Autophagy inhibitor inhibit