Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].
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Description | SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1]. |
Molecular Weight | 688.74 |
Formula | C36H36N10O5 |
CAS No. | 2595365-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SJ988497 2595365-41-4 inhibitor inhibit