Shopping Cart

Your shopping cart is currently empty

AF 12198 Acetate

Name: AF 12198 Acetate
Brand: TargetMol
SKU: T21644L
Price: 418 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21644L

Alias AF 12198 Acetate (185413-30-3 Free base)

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

AF 12198 Acetate

🥰Excellent

Purity: 95.27%

Catalog No. T21644LAlias AF 12198 Acetate (185413-30-3 Free base)

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$418	In Stock	In Stock
5 mg	$882	In Stock	In Stock
10 mg	$1,180	In Stock	In Stock
25 mg	$1,770	In Stock	In Stock
50 mg	$2,380	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$2,330	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.27%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
Targets&IC50	IL-8:25 nM
In vitro	?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1].
In vivo	When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].?
Synonyms	AF 12198 Acetate (185413-30-3 Free base)

Chemical Properties

Molecular Weight	1955.17
Formula	C₉₈H₁₂₇N₁₉O₂₄
Smiles	CC(O)=O.CC(C)C[C@@H](C(N)=O)NC([C@H]1N(C([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC2=CC=C(O)C=C2)N(C([C@H](CCC(N)=O)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC4=CNC5=C4C=CC=C5)NC(CNC([C@H]6N(C([C@H]([C@H](O)C)NC([C@H](CC7=CNC8=C7C=CC=C8)NC([C@H](CCC(O)=O)NC([C@H](CC9=CC=CC=C9)NC(C)=O)=O)=O)=O)=O)CCC6)=O)=O)=O)=O)=O)C(C%10NCC%10)=O)=O)=O)=O)CCC1)=O
Relative Density.	no data available
Sequence	Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2
Sequence Short	FEWTPGWYQXYALPL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (30.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5115 mL	2.5573 mL	5.1146 mL	25.5732 mL
5 mM	0.1023 mL	0.5115 mL	1.0229 mL	5.1146 mL
10 mM	0.0511 mL	0.2557 mL	0.5115 mL	2.5573 mL
20 mM	0.0256 mL	0.1279 mL	0.2557 mL	1.2787 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc