This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Patamostat
Catalog No. T9670 CAS
114568-26-2
Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin, exhibiting IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests that Patamostat might suppress the pathogenesis and development of acute pancreatitis [1] [2].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin, exhibiting IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests that Patamostat might suppress the pathogenesis and development of acute pancreatitis [1] [2].
In vivo
Patamostat, administered through intravenous infusion, demonstrates dose-dependent efficacy in reducing mortality in rats (0.03-0.3 mg/kg) and rabbits (0.3-3.0 mg/kg) following pancreatitis induction. In dogs afflicted with pancreatitis, patamostat in doses ranging from 1.0 to 3.0 mg/kg mitigates the elevation of serum trypsin and lipase levels. A specific study with male Wistar rats, using a continuous infusion of 2 mg/kg per hour of patamostat, showcases significant improvements across multiple parameters. These include a reduction in mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum Fibrin Degradation Products (FDP) levels, and normalized distribution of lysosomal enzyme. This study involved male Wistar rats, averaging a weight of about 350 g, with the dosage administered continuously per hour for 1 h, resulting in notably enhanced survival rates.
Molecular Weight
412.46
Formula
C20H20N4O4S
CAS No.
114568-26-2
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.