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CC260

Catalog No. T35874 CAS 2411088-26-9

CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].

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CC260, CAS 2411088-26-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,370.00
50 mg	6-8 weeks	$ 1,790.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].
Targets&IC50	PI5P4Kα:40 nM (Ki), PI5P4Kβ:30 nM (Ki)
In vitro	In cultured C2C12 myotubes, CC260 (20 μM) not only enhances insulin-induced phosphorylation of Akt at Thr-308 and Ser-473, but also inhibits S6K phosphorylation (Thr-389) mediated by mTORC1[1]. Furthermore, CC260, at concentrations ranging from 2.5 μM to 20 μM, progressively increases acetyl-CoA carboxylase (ACC) phosphorylation in a dose-dependent manner[1]. CC260 treatment diminishes the survival of BT474 cells under serum starvation, a condition that can be reversed by introducing a PI5P4Kβ resistant mutant[1]. Additionally, in BT474 cells, CC260 leads to an augmentation in glycolytic ATP production[1].

Molecular Weight	490.43
Formula	C24H29Cl2N5O2
CAS No.	2411088-26-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53- tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2002486118.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CC260 2411088-26-9 CC 260 CC-260 inhibitor inhibit

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