This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
N-Salicyloyltryptamine
Catalog No. T60526 CAS
31384-98-2
N-Salicyloyltryptamine(STP) is a tryptamine analogue with anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect. N-Salicyloyltryptamine acts as the voltage-dependent Na +, Ca 2+, and K + ion channels inhibitor which inhibits K + currents with an IC 50 value of 34.6 μM ( /to) [1] - [5].
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Contact us for more batch information
Biological Description
Chemical Properties
Storage
& Solubility Information
Description
N-Salicyloyltryptamine(STP) is a tryptamine analogue with anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect. N-Salicyloyltryptamine acts as the voltage-dependent Na +, Ca 2+, and K + ion channels inhibitor which inhibits K + currents with an IC 50 value of 34.6 μM ( /to) [1] - [5].
In vitro
N-Salicyloyltryptamine, at concentrations ranging from 1 ng/mL to 1 μg/mL over 24 hours, exhibits no cytotoxic effects or oxidative stress in RAW 264.7 cells at lower concentrations. However, at higher concentrations (50 and 100 μg/mL), it significantly reduces cell viability, demonstrating an IC 50 value of 22.75 μg/mL. At a concentration of 1 μg/mL for 24 hours, this compound counteracts certain redox and inflammatory markers induced by LPS without affecting cell viability. Furthermore, it effectively inhibits the release of LPS-induced TNF-α and IL-1β, as well as the up-regulation of CD40 and TNF-α proteins. It also blocks the phosphorylation of ERK 1/2 and IκBα, alongside preventing the nuclear translocation of p65, thus hindering NF-kB activation. At 17 μM, N-Salicyloyltryptamine significantly suppresses K+ currents by 59.27% (Ito) and 73.18% (IKD), L-type Ca2+ currents by 54.9%, and exerts a moderate inhibition of TTX-sensitive Na+ currents by 22.1% at a high concentration (170 μM) in GH3 cells. This compound induces vasorelaxation from 0.01 nM to 100 μM through the activation of the NO/sGC/cGMP pathway and reducing calcium influx. Assays on RAW 264.7 cells show at 1 μg/mL concentration, N-Salicyloyltryptamine maintains cell viability while reducing CD40, TNF-α, and RAGE immunocontent, and inhibiting the phosphorylation of ERK1/2 and IκBα, along with p65 nuclear translocation.
In vivo
N-Salicyloyltryptamine administered intraperitoneally (i.p.) at 100 mg/kg, 60 minutes before stimulation challenge, markedly diminishes pentylenetetrazol (PTZ)-induced seizures and mitigates the extensor reflex in maximal electric-induced seizure tests [4]. Furthermore, at dosages of 100 mg/kg and 200 mg/kg, it exhibits antinociceptive effects and reduces nerve excitability [5]. In studies involving male Swiss mice weighing 25-35 g, a single dose of N-Salicyloyltryptamine at 50 mg/kg significantly lowered both the occurrence of clonic PTZ seizures and mortality rates. The same compound, at 100 mg/kg and 200 mg/kg dosages, decreased the incidence of tonic hindlimb extension (THE) triggered by maximal electroshock (MES) [4]. Additionally, a single intraperitoneal injection of N-Salicyloyltryptamine at 100 mg/kg and 200 mg/kg notably lessened the licking response induced by acetic acid in the paw, illustrating its analgesic potential [5].
Molecular Weight
280.32
Formula
C17H16N2O2
CAS No.
31384-98-2
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
More
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.