Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 93.00 | |
5 mg | 35 days | $ 423.00 | |
10 mg | 35 days | $ 798.00 | |
25 mg | 35 days | $ 1,760.00 |
Description | R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex. |
Molecular Weight | 348.71 |
Formula | C16H8ClF3N4 |
CAS No. | 338773-13-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL
DMF: 16 mg/mL
DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL
You can also refer to dose conversion for different animals. More
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R-8507 338773-13-0 R8507 R 8507 inhibitor inhibit