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Smilagenin
😃Good
Catalog No. T4954LCas No. 126-18-1
Alias PYM50028, PYM 50028, Cogane, AI3-44895, AI344895
Smilagenin is a natural anthocyanin glycoside exhibiting AchE inhibitory activity (IC50 = 43.29 mg/L). It promotes CREB phosphorylation to increase GDNF and BDNF mRNA levels, attenuates Aβ(25-35)-induced neurodegeneration, and demonstrates neuroprotective and memory-enhancing effects.
Smilagenin
😃Good
Purity: 98%
Catalog No. T4954LAlias PYM50028, PYM 50028, Cogane, AI3-44895, AI344895Cas No. 126-18-1
Smilagenin is a natural anthocyanin glycoside exhibiting AchE inhibitory activity (IC50 = 43.29 mg/L). It promotes CREB phosphorylation to increase GDNF and BDNF mRNA levels, attenuates Aβ(25-35)-induced neurodegeneration, and demonstrates neuroprotective and memory-enhancing effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | - | In Stock | |
| 5 mg | $64 | - | In Stock | |
| 10 mg | $98 | - | In Stock | |
| 25 mg | $172 | - | In Stock | |
| 50 mg | $252 | - | In Stock | |
| 100 mg | $373 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Smilagenin is a natural anthocyanin glycoside exhibiting AchE inhibitory activity (IC50 = 43.29 mg/L). It promotes CREB phosphorylation to increase GDNF and BDNF mRNA levels, attenuates Aβ(25-35)-induced neurodegeneration, and demonstrates neuroprotective and memory-enhancing effects. |
| In vitro | In MPP+-treated SH-SY5Y cells, Smilagenin (10 μM, 24 hours) increased the mRNA levels of GDNF and BDNF by promoting CREB phosphorylation [2]. Smilagenin (10 μM, 24 hours) enhanced the survival rate of SH-SY5Y cells [3]. |
| In vivo | Smilagenin (10 or 26 mg/kg, intragastric administration, once daily for 60 days) has a protective effect against damage to dopaminergic neurons in a chronic MPTP/Probenecid-induced mouse model [2]. |
| Synonyms | PYM50028, PYM 50028, Cogane, AI3-44895, AI344895 |
| Molecular Weight | 416.64 |
| Formula | C27H44O3 |
| Cas No. | 126-18-1 |
| Smiles | C[C@@H]1[C@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H])[H])[H])[H])CC[C@@H](C)CO2 |
| Relative Density. | 1.11g/cm3 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble) Ethanol: ≥ 8 mg/mL, Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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