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AZ-GHS-22

Name: AZ-GHS-22
Brand: TargetMol
SKU: T37412
Rating: 4.5 (1 reviews)

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Catalog No. T37412Cas No. 1143020-91-0

AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.

AZ-GHS-22

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Catalog No. T37412Cas No. 1143020-91-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$265	35 days	35 days
5 mg	$1,130	35 days	35 days
10 mg	$1,980	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	621.17
Formula	C₂₇H₃₃ClN₆O₅S₂
Cas No.	1143020-91-0
Smiles	N(C(NC(=O)C1=CC(=CC=C1Cl)N2CCOCC2)=O)C=3SC=4C(N3)=CC=C(S(CCCN5CCN(C)CC5)(=O)=O)C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M HCl: 25 mg/mL (40.25 mM), Sonication is recommended.

DMSO: 50 mg/mL (80.49 mM), Sonication is recommended.

Solution Preparation Table

0.1 M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6099 mL	8.0493 mL	16.0987 mL	80.4933 mL
5 mM	0.3220 mL	1.6099 mL	3.2197 mL	16.0987 mL
10 mM	0.1610 mL	0.8049 mL	1.6099 mL	8.0493 mL
20 mM	0.0805 mL	0.4025 mL	0.8049 mL	4.0247 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0322 mL	0.1610 mL	0.3220 mL	1.6099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc