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(S)-UFR2709 hydrochloride

Catalog No. T37094

Synonyms: (S)-UFR2709 hydrochloride

(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(S)-UFR2709 hydrochloride Chemical Structure

(S)-UFR2709 hydrochloride, CAS N/A

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 83.00
10 mg	Inquiry	$ 124.00
25 mg	Inquiry	$ 249.00
50 mg	Inquiry	$ 374.00
100 mg	Inquiry	$ 581.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 91.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].
In vitro	Brain nicotinic acetylcholine receptors (nAChRs), a diverse group of pentameric acetylcholine-gated cation channels, serve as a molecular target for alcohol abuse and dependence treatment[1].
In vivo	(S)-UFR2709 (hydrochloride) (50-100 μg/ml) administrated for 3 minutes and then kept for another 5 minutes in a holding tank, significantly reduces bottom dwelling time in a Novel Tank Test (NTT), demonstrating a dose-dependent decrease to 52.9 and 87.0 seconds for 50 and 100 μg/ml, respectively[2]. This compound also diminishes nicotine-evoked mRNA expression of the α4 nACh receptor subunit in adult zebrafish brains, with a lesser effect at both concentrations[2]. Furthermore, when given as an intraperitoneal injection at 1-10 mg/kg daily for 17 days to high-alcohol-drinking UChB rats, (S)-UFR2709 markedly decreases ethanol consumption and preference, while increasing water consumption in a dose-dependent manner, with 2.5 mg/kg being the most effective, resulting in a 56% reduction in alcohol intake. Importantly, it does not impact the rats' weight or locomotor activity[1].

Synonyms	(S)-UFR2709 hydrochloride
Molecular Weight	N/A

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (195.51 mM)

References and Literature

1. Gabriel Quiroz, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Front Pharmacol. 2019 Dec 3;10:1429. 2. Franco Viscarra, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules. 2020 Jun 30;25(13):2998.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S)-UFR2709 hydrochloride (S)UFR2709 hydrochloride UFR2709 Hydrochloride UFR 2709 Hydrochloride (S) UFR2709 hydrochloride UFR-2709 Hydrochloride (S)-UFR-2709 hydrochloride inhibitor inhibit

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