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THI0019

Catalog No. T38793 CAS 1378532-99-0

Synonyms: THI0019

THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.

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THI0019, CAS 1378532-99-0

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,062.00
50 mg	Inquiry	$ 1,834.00

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Description	THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.
Targets&IC50	α4β1:1-2 μM (EC50)
In vitro	In assays evaluating Jurkat cell adhesion, when bound to CS1-conjugated BSA, THI0019 enhanced cell binding in a dose-dependent manner, achieving an effective concentration (EC 50) of 1.7 μM. A more significant, 100-fold increase in Jurkat cell attachment was observed when using VCAM-1 as the ligand, with THI0019 demonstrating an EC 50 of 1.2 μM. Additionally, THI0019 increased EPC binding to VCAM-1 in a dose-dependent fashion (EC 50 of 3.7 μM). It also augmented cell rolling and spreading on VCAM-1 and enhanced cell migration toward SDF-1α[1].

Synonyms	THI0019
Molecular Weight	601.73
Formula	C29H35N3O7S2
CAS No.	1378532-99-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Peter Vanderslice, et al. Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion. J Biol Chem. 2013 Jul 5;288(27):19414-28.

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Keywords

THI0019 1378532-99-0 THI-0019 THI 0019 inhibitor inhibit

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