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Xanthoxyletin

Name: Xanthoxyletin
Brand: TargetMol
SKU: TN5264
Price: 6070 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN5264Cas No. 84-99-1

Xanthoxyletin is a natural coumarin capable of inhibiting DPPH radicals, exhibiting cytotoxicity and apoptosis induction in HepG2, HCT116, and SK-LU-1 cancer cells, demonstrating antioxidant and anticancer potential.

Xanthoxyletin

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Catalog No. TN5264Cas No. 84-99-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$6,070	-	In Stock

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description

In vitro

Xanthoxyletin (1–500 µM; 30 min) inhibited DPPH radical scavenging with an IC₅₀ = 247.1 µM and iron reduction antioxidant capacity (FRAP) with an IC₅₀ = 45.2 µM [2].
Xanthoxyletin (10–500 µM; 24 h) exhibited cytotoxicity against HepG2, HCT116, and SK-LU-1 cancer cells with IC₅₀ values of 78.2/79.8/94.4 µM, respectively [2].
Xanthoxyletin (78 and 156 μM; 12 and 24 hours) induces apoptosis with low necrosis [2].

Chemical Properties

Molecular Weight	258.27
Formula	C₁₅H₁₄O₄
Cas No.	84-99-1
Smiles	O=C1OC2=CC=3OC(C=CC3C(OC)=C2C=C1)(C)C
Relative Density.	1.225g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc