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PI-55

Name: PI-55
Brand: TargetMol
SKU: T60390
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60390Cas No. 1122579-42-3

Alias 6-(2-hydroxy-3-methylbenzylamino)purine

PI-55 (6-(2-hydroxy-3-methylbenzylamino)purine) is a cytokinin receptor inhibitor that exhibits structural similarity to 6-benzylaminopurine (BAP). It competitively inhibits BAP binding on the specific Arabidopsis receptors CRE1/AHK4 and AHK3. Furthermore, PI-55 effectively suppresses cytokinins-induced haustorium formation and enhances parasite aggressiveness [1].

PI-55

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Purity: 98.59%

Catalog No. T60390Alias 6-(2-hydroxy-3-methylbenzylamino)purineCas No. 1122579-42-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$448	In Stock	In Stock
25 mg	$768	In Stock	In Stock
50 mg	$1,070	In Stock	In Stock
100 mg	$1,380	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$327	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.59%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PI-55 (6-(2-hydroxy-3-methylbenzylamino)purine) is a cytokinin receptor inhibitor that exhibits structural similarity to 6-benzylaminopurine (BAP). It competitively inhibits BAP binding on the specific Arabidopsis receptors CRE1/AHK4 and AHK3. Furthermore, PI-55 effectively suppresses cytokinins-induced haustorium formation and enhances parasite aggressiveness [1].
In vitro	High concentrations of PI-55 (10 μM and 100 μM) result in partial inhibition of early haustorial structure development, particularly in the presence of cytokinin. Further, PI-55 treatment, when combined with BAP, diminishes the virulence of P. ramosa compared to the application of BAP alone. This suggests the involvement of histidine kinase receptors analogous to CRE1/AHK4 and AHK3 in the signaling pathway that initiates early haustorial formation [1].
Synonyms	6-(2-hydroxy-3-methylbenzylamino)purine

Chemical Properties

Molecular Weight	255.28
Formula	C₁₃H₁₃N₅O
Cas No.	1122579-42-3
Smiles	Cc1cccc(CNc2ncnc3[nH]cnc23)c1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (97.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9173 mL	19.5863 mL	39.1727 mL	195.8634 mL
5 mM	0.7835 mL	3.9173 mL	7.8345 mL	39.1727 mL
10 mM	0.3917 mL	1.9586 mL	3.9173 mL	19.5863 mL
20 mM	0.1959 mL	0.9793 mL	1.9586 mL	9.7932 mL
50 mM	0.0783 mL	0.3917 mL	0.7835 mL	3.9173 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc