Propargyl-PEG4-Tos

Name: Propargyl-PEG4-Tos
Brand: TargetMol
SKU: T16635
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16635Cas No. 875770-32-4

Propargyl-PEG4-Tos is a PEG-based PROTAC linker used in the synthesis of PROTACs and cleavable ADC linkers for antibody-drug conjugate (ADC) synthesis [1][2].

Propargyl-PEG4-Tos

🥰Excellent

Catalog No. T16635Cas No. 875770-32-4

Propargyl-PEG4-Tos is a PEG-based PROTAC linker used in the synthesis of PROTACs and cleavable ADC linkers for antibody-drug conjugate (ADC) synthesis [1][2].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Resource Download

COA

Product Introduction

Bioactivity

Description	Propargyl-PEG4-Tos is a PEG-based PROTAC linker used in the synthesis of PROTACs and cleavable ADC linkers for antibody-drug conjugate (ADC) synthesis [1][2].
In vitro	PROTACs, composed of two ligands linked together—one for an E3 ubiquitin ligase and the other for the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs consist of an antibody linked to a cytotoxin via an ADC linker.

Chemical Properties

Molecular Weight	386.46
Formula	C₁₈H₂₆O₇S
Cas No.	875770-32-4
Relative Density.	1.177 g/cm3 (Predicted)
Color	Yellow
Appearance	Liquid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc