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Skyrin

Name: Skyrin
Brand: TargetMol
SKU: T36072
Rating: 4.5 (1 reviews)

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Catalog No. T36072Cas No. 602-06-2

Alias Rhodophyscin, Endothianin

Skyrin is a natural bis-anthraquinone derivative and receptor-selective glucagon antagonist that inhibits the growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumour cell lines.

Skyrin

😃Good

Catalog No. T36072Alias Rhodophyscin, EndothianinCas No. 602-06-2

Skyrin is a natural bis-anthraquinone derivative and receptor-selective glucagon antagonist that inhibits the growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumour cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$458	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:Orange

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Product Introduction

Bioactivity

Description	Skyrin is a natural bis-anthraquinone derivative and receptor-selective glucagon antagonist that inhibits the growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumour cell lines.
In vitro	Methods: Skyrin (0.0001–100 μM) was treated with plasmid DNA. The effects of skyrin on plasmid DNA were investigated using DNA topology. The potential DNA protection against Fe2+-induced DNA breaks was also assessed. Results: Skyrin at all tested concentrations (0.0001–100 μM) showed no DNA damaging properties (Figure 1). The ability of skyrin to protect plasmid DNA increased in a concentration-dependent manner, and strong DNA protection was observed in samples with higher skyrin concentrations (5–100 μM). [2]
Synonyms	Rhodophyscin, Endothianin

Chemical Properties

Molecular Weight	538.46
Formula	C₃₀H₁₈O₁₀
Cas No.	602-06-2
Smiles	O=C1C2=CC(=CC(O)=C2C(=O)C=3C(O)=CC(O)=C(C13)C=4C(O)=CC(O)=C5C(=O)C6=C(O)C=C(C=C6C(=O)C54)C)C

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Ethanol: Soluble DMSO: Soluble

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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