Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (CRP)-induced NLRP3 inflammasome activation. It is utilized in atherosclerosis research [1] [2].
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Description | Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (CRP)-induced NLRP3 inflammasome activation. It is utilized in atherosclerosis research [1] [2]. |
In vitro | Oxidized ATP trisodium salt at a concentration of 100 μM for 1 hour inhibits the activation of caspase-1 and the maturation of IL-1β induced by CRP at 20 μg/mL for 24 hours in HUVECs [1]. |
In vivo | Oxidized ATP trisodium salt (300 μg/mouse, i.p., twice a week) mitigates experimentally induced autoimmune uveitis (EAU) in B6 mice [2]. |
Synonyms | oATP trisodium salt |
Molecular Weight | 571.11 |
Formula | C10H11N5Na3O13P3 |
CAS No. | 71997-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Oxidized ATP trisodium salt 71997-40-5 Membrane transporter/Ion channel Neuroscience P2X Receptor oATP trisodium salt inhibitor inhibit