Oxidized ATP trisodium salt

Name: Oxidized ATP trisodium salt
Brand: TargetMol
SKU: T78639
Rating: 4.5 (1 reviews)

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Catalog No. T78639Cas No. 71997-40-5

Alias oATP trisodium salt

Oxidized ATP trisodium salt (oATP) is a broad-spectrum P2 receptor inhibitor that irreversibly antagonizes P2X7R activation and inhibits CRP-induced NLRP3 inflammasome activation, making it useful in atherosclerosis research [1] [2].

Oxidized ATP trisodium salt

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Catalog No. T78639Alias oATP trisodium saltCas No. 71997-40-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Oxidized ATP trisodium salt (oATP) is a broad-spectrum P2 receptor inhibitor that irreversibly antagonizes P2X7R activation and inhibits CRP-induced NLRP3 inflammasome activation, making it useful in atherosclerosis research [1] [2].
In vitro	Oxidized ATP trisodium salt at a concentration of 100 μM for 1 hour inhibits the activation of caspase-1 and the maturation of IL-1β induced by CRP at 20 μg/mL for 24 hours in HUVECs [1].
In vivo	Oxidized ATP trisodium salt (300 μg/mouse, i.p., twice a week) mitigates experimentally induced autoimmune uveitis (EAU) in B6 mice [2].
Synonyms	oATP trisodium salt

Chemical Properties

Molecular Weight	571.11
Formula	C₁₀H₁₁N₅Na₃O₁₃P₃
Cas No.	71997-40-5
Smiles	O=P([O-])([O-])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O)=O)([O-])=O.[Na+].[Na+].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc