Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 24, also known as Mu opioid receptor antagonist 7, is a potent, centrally-acting µ-opioid receptor (µOR) antagonist with an inhibitory concentration (IC50) of 29 ± 3.0 nM. It is valuable for pain and opioid use disorder research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | Compound 24, also known as Mu opioid receptor antagonist 7, is a potent, centrally-acting µ-opioid receptor (µOR) antagonist with an inhibitory concentration (IC50) of 29 ± 3.0 nM. It is valuable for pain and opioid use disorder research [1]. |
Targets&IC50 | μ opioid receptor:29 nM |
In vivo | Mu opioid receptor antagonist 7 (compound 24) at a dose of 10 mg/kg effectively blocks the analgesic effect induced by µOR agonists, demonstrating its ability to antagonize µOR agonists [1]. At the same dose and in rats, it reverses the respiratory depression caused by fentanyl, a potent µOR agonist. Administered subcutaneously in rats, it achieves 70% µOR receptor occupancy, indicating high central nervous system (CNS) penetrability [1]. |
Molecular Weight | 386.91 |
Formula | C22H27ClN2O2 |
CAS No. | 2378397-30-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Mu opioid receptor antagonist 7 2378397-30-7 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibitor inhibit