Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fludarabine triphosphate (F-ara-ATP) trisodium, the principal metabolite of Fludarabine, acts as a potent, noncompetitive, and specific inhibitor of DNA primase, exhibiting an IC50 value of 2.3 μM and a Ki of 6.1 μM. It hampers DNA synthesis by obstructing DNA primase and the formation of primer RNA, while also inhibiting ribonucleotide reductase and DNA polymerase activities, effectively inducing cellular apoptosis [1] [2].
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Description | Fludarabine triphosphate (F-ara-ATP) trisodium, the principal metabolite of Fludarabine, acts as a potent, noncompetitive, and specific inhibitor of DNA primase, exhibiting an IC50 value of 2.3 μM and a Ki of 6.1 μM. It hampers DNA synthesis by obstructing DNA primase and the formation of primer RNA, while also inhibiting ribonucleotide reductase and DNA polymerase activities, effectively inducing cellular apoptosis [1] [2]. |
Molecular Weight | 591.12 |
Formula | C10H12FN5Na3O13P3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Fludarabine triphosphate trisodium inhibitor inhibit