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α-Methyl-DL-aspartic acid

Name: α-Methyl-DL-aspartic acid
Brand: TargetMol
SKU: T78044
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78044Cas No. 2792-66-7

α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.

α-Methyl-DL-aspartic acid

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Purity: 99.91%

Catalog No. T78044Cas No. 2792-66-7

α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	-	In Stock
10 mg	$40	-	In Stock
25 mg	$81	-	In Stock
50 mg	$129	-	In Stock
100 mg	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.
In vitro	α-Methyl-dl-aspartic acid markedly diminishes the antihypertensive effects of Bj-BPP-10c in spontaneously hypertensive rats (SHR) [2].
In vivo	α-Methyl-DL-aspartic acid (147 mg/kg, intravenous injection) was used to treat L-citrulline-induced retinal vasodilation in Wistar rats and was found to reduce retinal vasodilation in rats. [1]

Chemical Properties

Molecular Weight	147.13
Formula	C₅H₉NO₄
Cas No.	2792-66-7
Smiles	O=C(O)CC(N)(C(=O)O)C
Sequence	H-DL-aMeAsp-OH
Sequence Short	X

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (271.87 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7967 mL	33.9836 mL	67.9671 mL	339.8355 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL	67.9671 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL	33.9836 mL
20 mM	0.3398 mL	1.6992 mL	3.3984 mL	16.9918 mL
50 mM	0.1359 mL	0.6797 mL	1.3593 mL	6.7967 mL
100 mM	0.0680 mL	0.3398 mL	0.6797 mL	3.3984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc