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Topsalysin
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Catalog No. T80966Cas No. 917121-25-6
Alias PRX-302
Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1].
Topsalysin
Topsalysin
😃Good
Catalog No. T80966Alias PRX-302Cas No. 917121-25-6
Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1]. |
| In vitro | Topsalysin (19 pM-10 nM; 48 hours) demonstrates PSA-dependent cytotoxicity in LNCaP, PC3, DU145, and TSU cell lines [1]. |
| In vivo | Topsalysin (intra-tumoral injection; 1-10 μg/mouse; single dose) inhibits tumor growth in mice [1]. In addition, a single intraperitoneal injection of Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL) killed up to 50% of the cells at the prostate injection site in cynomolgus monkeys [1]. |
| Synonyms | PRX-302 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | human prostate-specific antigen |
| Cas No. | 917121-25-6 |
| Storage | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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