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Topsalysin (Synonyms: PRX-302)
Catalog No. T80966 Copy Product Info
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Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1].
Topsalysin
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Catalog No. T80966
Synonyms PRX-302
Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1].
Topsalysin
Cas No. 917121-25-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Related Conjugates and Formulations
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| Description | Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1]. |
| In vitro | Topsalysin (19 pM-10 nM; 48 hours) demonstrates PSA-dependent cytotoxicity in LNCaP, PC3, DU145, and TSU cell lines [1]. |
| In vivo | Topsalysin (intra-tumoral injection; 1-10 μg/mouse; single dose) inhibits tumor growth in mice [1]. In addition, a single intraperitoneal injection of Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL) killed up to 50% of the cells at the prostate injection site in cynomolgus monkeys [1]. |
| Synonyms | PRX-302 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | human prostate-specific antigen |
| Cas No. | 917121-25-6 |
| Storage | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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