Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1].
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Description | Topsalysin, a prostate-specific antigen (PSA)-activated protoxin, comprises a synthetic proaerolysin fusion protein targeting human prostate-specific antigen. This compound has demonstrated tumor-suppressive effects in a mouse model [1]. |
In vitro | Topsalysin (19 pM-10 nM; 48 hours) exhibits prostate-specific antigen (PSA)-dependent cytotoxicity in LNCaP, PC3, DU145, and TSU cell lines [1]. |
In vivo | Topsalysin (肿瘤内注射; 1-10μg/鼠标; 单次剂量) inhibited tumor growth in mice [1]. Additionally, a single intraperitoneal dose of Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL) killed up to 50% of cells at the injection site in the prostate of cynomolgus monkeys [1]. |
Synonyms | PRX-302 |
Molecular Weight | N/A |
CAS No. | 917121-25-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Topsalysin 917121-25-6 PRX-302 inhibitor inhibit