Villocarine A, an indole alkaloid with natural vasorelaxant properties [1], is a chemical compound known for its ability to relax blood vessels.

Villocarine A demonstrated significant efficacy shortly after administration, showing potent vasorelaxant properties at a concentration of 30 μM in counteracting PE-induced contraction in rat aortic tissue within 10-30 minutes post-injection. Additionally, at the same concentration, Villocarine A presented a moderate inhibitory effect on contractions incited by PE and 1 μM in aortic rings under the conditions of a Ca2+-free medium and in the presence of nicardipine (1 μM) [2].