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Licarin A

Name: Licarin A
Brand: TargetMol
SKU: T20728
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20728Cas No. 51020-86-1

Alias (-)-Licarin A

Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.

Licarin A

🥰Excellent

Purity: 99.5%

Catalog No. T20728Alias (-)-Licarin ACas No. 51020-86-1

Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$200	In Stock
10 mg	$295	In Stock
25 mg	$497	In Stock

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Purity:99.5%

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Product Introduction

Bioactivity

Description	Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.
In vitro	Methods: DNP-HSA-stimulated RBL-2H3 cells were treated with Licarin A (0-20 μM) to study the antiallergic effect on antigen-stimulated rat mast cell line. Results: The level of PGD2 secretion in DNP-HSA-stimulated cells pretreated with Licarin A was lower than that in cells stimulated with DNP-HSA alone (positive control); 20 μM Licarin A treatment produced a slight inhibition of DNP-HSA-induced increase in COX-2 mRNA and protein levels; Licarin A reduced TNF-α and PGD2 secretion by inhibiting PKCα/βII and p38 MAPK pathways; this compound may be useful in alleviating immediate hypersensitivity reactions. [5]
Synonyms	(-)-Licarin A

Chemical Properties

Molecular Weight	326.39
Formula	C₂₀H₂₂O₄
Cas No.	51020-86-1
Smiles	O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1
Relative Density.	1.16g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (122.55 mM), Sonication is recommended.

H2O: < 0.1(insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL	153.1910 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL	30.6382 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL	15.3191 mL
20 mM	0.1532 mL	0.7660 mL	1.5319 mL	7.6595 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0638 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5319 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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