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Licarin A

Name: Licarin A
Brand: TargetMol
SKU: T20728
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20728Cas No. 51020-86-1

Alias (-)-Licarin A

Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.

Licarin A

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Purity: 99.5%

Catalog No. T20728Alias (-)-Licarin ACas No. 51020-86-1

Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$200	In Stock	In Stock
10 mg	$295	-	In Stock
25 mg	$497	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.5%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.
In vitro	Methods: DNP-HSA-stimulated RBL-2H3 cells were treated with Licarin A (0-20 μM) to study the antiallergic effect on antigen-stimulated rat mast cell line. Results: The level of PGD2 secretion in DNP-HSA-stimulated cells pretreated with Licarin A was lower than that in cells stimulated with DNP-HSA alone (positive control); 20 μM Licarin A treatment produced a slight inhibition of DNP-HSA-induced increase in COX-2 mRNA and protein levels; Licarin A reduced TNF-α and PGD2 secretion by inhibiting PKCα/βII and p38 MAPK pathways; this compound may be useful in alleviating immediate hypersensitivity reactions. [5]
Synonyms	(-)-Licarin A

Chemical Properties

Molecular Weight	326.39
Formula	C₂₀H₂₂O₄
Cas No.	51020-86-1
Smiles	O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1
Relative Density.	1.16g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (122.55 mM), Sonication is recommended.

H2O: < 0.1(insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL	153.1910 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL	30.6382 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL	15.3191 mL
20 mM	0.1532 mL	0.7660 mL	1.5319 mL	7.6595 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0638 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5319 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc