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TrkA-IN-4

Name: TrkA-IN-4
Brand: TargetMol
SKU: T73307
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73307 Copy Product Info

Purity: 99.97%

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TrkA-IN-4 is a highly potent, orally active TrkA allosteric inhibitor that is metabolized in vivo as a prodrug to its active form, TrkA-IN-3. TrkA-IN-4 has demonstrated effective anti-injury effects.

Cas No. 3026111-74-7

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$39	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TrkA-IN-4 is a highly potent, orally active TrkA allosteric inhibitor that is metabolized in vivo as a prodrug to its active form, TrkA-IN-3. TrkA-IN-4 has demonstrated effective anti-injury effects.
In vivo	TrkA-IN-4 (0.9375-120 mg/kg; i.g.) exhibits stronger maximum antinociceptive effects 3 h after administration, with an ED50 of 7.836 mg/kg in hot plate testing on male mice.[1]

Chemical Properties

Molecular Weight	538.48
Formula	C₂₇H₂₁F₃N₄O₅
Cas No.	3026111-74-7
Smiles	FC(F)(F)C1=C(C2=NN(C)C=C2)C=C(C(NC3=C(C4=CC=CC=C4)N=CC(C(OCOC(C)=O)=O)=C3)=O)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (74.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8571 mL	9.2854 mL	18.5708 mL	92.8540 mL
5 mM	0.3714 mL	1.8571 mL	3.7142 mL	18.5708 mL
10 mM	0.1857 mL	0.9285 mL	1.8571 mL	9.2854 mL
20 mM	0.0929 mL	0.4643 mL	0.9285 mL	4.6427 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8571 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: TrkA-IN-4 chemical structure | TrkA-IN-4 in vivo | TrkA-IN-4 formula | TrkA-IN-4 molecular weight