Claudin-9 Protein, Human, Recombinant

Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It forms heterotypic interactions with other claudins to create cation-selective channels in the kidney and may contribute to the maintenance of alveolar barrier function in the lung. Deficiency is shown to be associated with autosomal recessive deafness, DFNB116. CLDN9 expression has been shown to be upregulated in certain types of cancer, such as endometrial cancer and hepatocellular carcinoma, and its knockdown has been found to reduce cell proliferation and migration in vitro.

Pack Size	Availability	Price/USD
20 μg	5 days	$ 1,000.00
100 μg	5 days	$ 2,110.00
500 μg	5 days	$ 7,450.00

Pack Size

Availability

Price/USD

Quantity

20 μg

5 days

$ 1,000.00

100 μg

5 days

$ 2,110.00

500 μg

5 days

$ 7,450.00

Description

Species	Human
Expression System	HEK293
Tag	Tag Free
Accession Number	O95484
Construction	A DNA sequence encoding the human CLDN9 (O95484) (Met1-Val217) was expressed.
Molecular Weight	Approxiamtely 22.9 kDa

Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Supplied as sterile 50mM Hepes, 150mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	It is supplied and shipped as Solution with dry ice.
Research Background	Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It forms heterotypic interactions with other claudins to create cation-selective channels in the kidney and may contribute to the maintenance of alveolar barrier function in the lung. Deficiency is shown to be associated with autosomal recessive deafness, DFNB116. CLDN9 expression has been shown to be upregulated in certain types of cancer, such as endometrial cancer and hepatocellular carcinoma, and its knockdown has been found to reduce cell proliferation and migration in vitro.