Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). Additionally, it inhibits the transmembrane isoforms of human carbonic anhydrase IX and XII with nanomolar class Ki values. Demonstrating analgesic and anti-inflammatory properties, COX-2-IN-30 is devoid of acute gastric effects, avoiding ulcerogenic activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). Additionally, it inhibits the transmembrane isoforms of human carbonic anhydrase IX and XII with nanomolar class Ki values. Demonstrating analgesic and anti-inflammatory properties, COX-2-IN-30 is devoid of acute gastric effects, avoiding ulcerogenic activity [1]. |
Targets&IC50 | hCA IX:38.4 nM (Ki), hCA XII:21.6 nM (Ki), 5-LOX:2.4 μM, COX-2:49 nM, hCA II:81.4 nM (Ki), hCA I:183.4 nM (Ki), COX-1:10.4 μM |
In vitro | COX-2-IN-30 (Compound 7a) binds to human carbonic anhydrase (hCA) isozymes, with inhibitory constants (K i values) of 183.4 nM (hCA I), 81.4 nM (hCA II), 38.4 nM (hCA IX), and 21.6 nM (hCA XII) [1]. |
In vivo | COX-2-IN-30 (化合物 7a) administered orally at a single dose of 10 mg/kg exhibited analgesic activity by significantly reducing the writhing frequency in mice [1]. Additionally, in the carrageenan-induced rat paw edema test, COX-2-IN-30 significantly decreased paw swelling. The compound also notably reduced the levels of pro-inflammatory cytokines TNF-α and IL-1β [1]. Furthermore, COX-2-IN-30 demonstrated safety in the gastric tissues of male albino rats at the same dosage and administration method [1]. |
Molecular Weight | 384.41 |
Formula | C17H16N6O3S |
CAS No. | 1160498-08-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
COX-2-IN-30 1160498-08-7 Immunology/Inflammation Neuroscience COX inhibitor inhibit