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Aβ-IN-6

Catalog No. T78698

Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's disease (AD) research [1]. It effectively reduces the release of pro-inflammatory cytokines from microglia cells, promotes Nrf2 nuclear translocation, and impedes the formation of Aβ oligomers. Furthermore, Aβ-IN-6 demonstrates a stable neuroprotective effect by modulating redox-sensitive signaling pathways in an in vivo oxidative stress model.

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Aβ-IN-6, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's disease (AD) research [1]. It effectively reduces the release of pro-inflammatory cytokines from microglia cells, promotes Nrf2 nuclear translocation, and impedes the formation of Aβ oligomers. Furthermore, Aβ-IN-6 demonstrates a stable neuroprotective effect by modulating redox-sensitive signaling pathways in an in vivo oxidative stress model.
In vitro	Aβ-IN-6 (Compound 4; 1-20 μM; 24 hours) significantly reduces microglial cell viability starting at a concentration of 5 μM [1]. At concentrations above 2.5 μM, Aβ-IN-6 (1.25-40 μM; 24 hours) shows notable cytotoxicity in SH-SY5Y neuroblastoma cells [1]. Aβ-IN-6 (2.5 μM; 3 hours) significantly induces Nrf2 nuclear translocation [1]. Aβ-IN-6 at 2.5 μM significantly inhibits the increase in levels of two cytokines and NLRP3 mRNA induced by LPS [1]. With pre-treatment of 1 and 2.5 μM for 1 hour followed by LPS stimulation for 24 hours, Aβ-IN-6 considerably reduces the release of TNF-α and IL-1β induced by LPS [1]. Pre-treatment with Aβ-IN-6 (2.5 μM; 24 hours) prior to exposure to tert-butyl hydrogen peroxide (t-BuOOH; 50 μM for 30 minutes) reduces ROS formation by approximately 18% [1].
In vivo	Aβ-IN-6 (Compound 4; 10 μM; added to standard food) effectively reduced the elevated levels of ROS in the muscles and brains of larvae with neurodegenerative disease (D-spastin loss-of-function model) back to the control levels observed in the Spastin fruit fly model [1].

Molecular Weight	473.56
Formula	C28H31N3O4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aβ-IN-6 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.