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BCL6-IN-4

Name: BCL6-IN-4
Brand: TargetMol
SKU: T36484
Rating: 4.5 (1 reviews)

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Catalog No. T36484Cas No. 2253879-65-9

Alias BCL6-IN-4

BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].

BCL6-IN-4

😃Good

Catalog No. T36484Alias BCL6-IN-4Cas No. 2253879-65-9

BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,900	8-10 weeks	8-10 weeks
50 mg	$2,480	8-10 weeks	8-10 weeks
100 mg	$3,700	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].
Targets&IC50	Bcl-6:97 nM (IC50)
In vitro	BCL6-IN-4 (compound 25b) inhibits the growth of OCI-Ly1 and OCI-Ly3 cell lines, with GI50 values of 2.8 μM and 4.2 μM, respectively[1].
Synonyms	BCL6-IN-4

Chemical Properties

Molecular Weight	503.04
Formula	C₂₅H₃₅ClN₆O₃
Cas No.	2253879-65-9
Smiles	Cn1c2ccc(Nc3nc(ncc3Cl)N3CC(C)(C)OC(C)(C)C3)cc2n(CCC(C)(C)O)c1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 73.33 mg/mL (145.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9879 mL	9.9396 mL	19.8791 mL	99.3957 mL
5 mM	0.3976 mL	1.9879 mL	3.9758 mL	19.8791 mL
10 mM	0.1988 mL	0.9940 mL	1.9879 mL	9.9396 mL
20 mM	0.0994 mL	0.4970 mL	0.9940 mL	4.9698 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9879 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc