Delmitide acetate

Name: Delmitide acetate
Brand: TargetMol
SKU: T78508
Rating: 4.5 (1 reviews)

(Synonyms: RDP-58 acetate) Copy Product Info

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Synonyms: RDP-58 acetate

Catalog No. T78508 Copy Product Info

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Delmitide acetate (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory properties, suppressing TNF-α, IFN-γ, and interleukin (IL)-12 production, while enhancing heme oxygenase 1 activity. It is utilized in research related to ulcerative colitis [1] [2].

Cas No. 501019-16-5

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$65	5 days	5 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Delmitide acetate (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory properties, suppressing TNF-α, IFN-γ, and interleukin (IL)-12 production, while enhancing heme oxygenase 1 activity. It is utilized in research related to ulcerative colitis [1] [2].
In vivo	Delmitide acetate administered orally at doses of 2.5, 5, and 10 mg/kg daily markedly mitigated CPT-11-induced diarrhea, mucosal inflammation, and mortality in mice by inhibiting the excessive synthesis of proinflammatory cytokines, including TNF-a, IFN-y, and IL-12, in vivo [2]. Furthermore, it fostered an improved tumor response and extended the duration until relapse, all without concurrent gastrointestinal toxicity in the mice [2].
Synonyms	RDP-58 acetate

Chemical Properties

Molecular Weight	1288.62
Formula	C₆₁H₁₀₉N₁₇O₁₃
Cas No.	501019-16-5
Smiles	C(C)(O)=O.[C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCC)=O)CCCC)=O)CCCC)=O)(C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@H](CC1=CC=C(O)C=C1)C(N)=O)=O)=O)CCCC)=O)CCCC)=O)CCCC)=O)CCCNC(=N)N
Sequence	{D-Arg}-{D-Nle}-{D-Nle}-{D-Nle}-{D-Arg}-{D-Nle}-{D-Nle}-{D-Nle}-{D-Gly}-{D-Tyr}-NH₂
Sequence Short	RXXXRXXXGY

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc