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IRAK4-IN-28
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Catalog No. T79337Cas No. 2952532-92-0
IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation and autoimmune diseases [1].
IRAK4-IN-28
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Catalog No. T79337Cas No. 2952532-92-0
IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation and autoimmune diseases [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,970 | 8-10 weeks | 8-10 weeks | |
| 50 mg | $2,580 | 8-10 weeks | 8-10 weeks | |
| 100 mg | $3,400 | 8-10 weeks | 8-10 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation and autoimmune diseases [1]. |
| In vitro | IRAK4-IN-28 does not inhibit cytochrome P450 enzymes CYP1A2, CYP2D6, CYP3A4, and hERG, indicating favorable safety and 'drug-like' properties [1]. However, it inhibits CYP2C9 and CYP2C19 with IC50 values of 12 μM and 2.7 μM, respectively [1]. It also exhibits high plasma protein binding in humans and rats (99.8% and 97.2%, respectively) [1]. Furthermore, IRAK4-IN-28 (1 h) dose-dependently suppresses LPS-induced TNF-α and IL-6 expression at mRNA and protein levels [1]. |
| In vivo | IRAK4-IN-28 (compound 42) exhibits favorable pharmacokinetic data in a rat model, with an oral bioavailability utilization rate of 68% [1]. A single oral dose of IRAK4-IN-28 at 50 or 100 mg/ml significantly reduces LPS-induced TNF-α and IL-6 cytokine release in a mouse model [1]. |
| Molecular Weight | 529.59 |
| Formula | C27H31N9O3 |
| Cas No. | 2952532-92-0 |
| Smiles | C(NC=1N=C(C=CC1)C=2C=NN(C)C2)(=O)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CCN(CC6)C7CC7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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