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HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)
(Synonyms: HOXB4, HOX2F, Homeobox protein Hox-B4, Homeobox protein Hox-2F, Homeobox protein Hox-2.6) Copy Product InfoSynonyms: HOXB4, HOX2F, Homeobox protein Hox-B4, Homeobox protein Hox-2F, Homeobox protein Hox-2.6
Catalog No. TMPJ-00879 Copy Product Info
Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $183 | 35 days | 35 days | |
| 20 µg | $292 | 35 days | 35 days | |
| 50 µg | $545 | 35 days | 35 days | |
| 100 µg | $813 | 35 days | 35 days | |
| 200 µg | $1,190 | 35 days | 35 days | |
| 500 µg | $2,070 | 35 days | 35 days | |
| 1 mg | $2,970 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-6xHis |
| Accession Number | P17483 |
| Amino Acid | Met1-Leu251 |
| Construction | Met1-Leu251 (Leu175Asp, Glu176Lys, Glu178Lys) |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 4 mM HCl. |
| Synonyms | HOXB4, HOX2F, Homeobox protein Hox-B4, Homeobox protein Hox-2F, Homeobox protein Hox-2.6 |
| Research Background | Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. |
| Molecular Weight | 36 KDa (reducing condition) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His) chemical structure | HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His) molecular weight
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