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HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)

Catalog No. TMPJ-00879
Synonyms: Homeobox protein Hox-2.6, HOX2F, HOXB4, Homeobox protein Hox-2F, Homeobox protein Hox-B4

Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 2,070.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Description Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Species Human
Expression System E. coli
Tag N-6His
Accession Number P17483
Synonyms Homeobox protein Hox-2.6, HOX2F, HOXB4, Homeobox protein Hox-2F, Homeobox protein Hox-B4
Amino Acid Met1-Leu251
Construction Recombinant Human Homeobox Protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 (Leu175Asp, Glu176Lys, Glu178Lys) is expressed with a 6His tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 36 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 4mM HCl.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

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Keywords

HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His) Homeobox protein Hox-2.6 HOX2F HOXB4 Homeobox protein Hox-2F HOXB-4 HOXB 4 Homeobox protein Hox-B4 recombinant recombinant-proteins proteins protein

 

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